In a message dated 7/4/01 9:53:01 AM Eastern Daylight Time,
[log in to unmask] writes:

>  Methotrexate's
>  half-life is 7.2 hours, according to Hale.  Five half-lives is 36 hours.
>  Throw in another for good measure and you're still talking less than two
>  days' bfing hiatus out of the three weeks or so between doses.

Dear Friends:
    Diane has posted a lovely note about methotrexate. However, a phrase she
used pushed a button for me. This in no way lessens the message of her post,
or the joy, power, and expertise she offers to us all.
    The phrase "...throw in another for good measure" is a fundamental
concept     that turns scientifically based recommendations into advice.
People all have their own versions of what a "good measure" is, and they are
generous in sharing their thoughts.  I have seen it when women are advised to
pump and dump for "X" hours,sometimes days, after having some alcohol or a
prescription medication, when the evidence is to the contrary.
    All of us need to be careful about this language.
    Now, another question. I have used the  five half-lives rule because I
have learned it from physicians. Does anyone know where the evidence for it
comes from?
    Warmly,
Nikki Lee RN, MSN, Mother of 2, IBCLC, CIMI
craniosacral therapy practitioner; childbirth educator
Elkins Park (a suburb of Philadelphia, Pennsylvania; northeastern USA)
supporting the WHO Code and the Mother Friendly Childbirth Initiative

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