Dear Louanne:
You can find info about cinitapride in www.e-lactancia.org
This web page is run by Spanish pediatricians and pharmacists. The web is
bilingual Spanish-English.
http://www.e-lactancia.org/breastfeeding/cinitapride/product/
Low Risk probable for breastfeeding
Moderately safe.
Mild risk possible. Follow up recommended.
Read the Comment:
Benzamide-type drug that is similar to Cisapride.
At latest update no published data on excretion into breast milk were found.
Drug that is poorly documented in the scientific literature. It seems to be
lacking of side effects (QT-interval prolongation, cardiac arrhythmias)
that led to the withdrawal of Cisapride.
Until more published information about this drug regarding breastfeeding
appears, it may be preferable a known and safer alternative, especially
during the neonatal period and in cases of prematurity.
Pharmacokinetics
VariableValueUnits
* Molecular weight * 403 daltons
* Time to max, Tmax * 2 hours
* Elimination half-life, T1/2 * 3 - 5 hours
1. Du Y, Su T, Song X, Gao J, Zou D, Zuo C, Xie W, Wang B, Zhang Z, Xu
J, Tian D, Luo H, Zhang Z, Wang S, Chen J, Guo J, Gong L, Ding Y,
Li Z. *Efficacy
and safety of cinitapride in the treatment of mild to moderate postprandial
distress syndrome-predominant functional dyspepsia.* *J Clin
Gastroenterol. * *2014* Abstract
<http://www.ncbi.nlm.nih.gov/pubmed/24440931>
2. Baqai MT, Malik MN, Ziauddin F. *Efficacy and safety of cinitapride
in functional dyspepsia.* *J Pak Med Assoc. * *2013* Abstract
<http://www.ncbi.nlm.nih.gov/pubmed/23901678>
3. Castro FJ, Saavedra J, López F, Herrera S, Bragulat E. *[Acute
cinitapride poisoning].* *Gastroenterol Hepatol. * *2011* Abstract
<http://www.ncbi.nlm.nih.gov/pubmed/21704434>
4. Mearín F, Plazas MJ, Mas M, Heras J. *[Cardiac safety of
cinitapride].* *Gastroenterol Hepatol. * *2010* Abstract
<http://www.ncbi.nlm.nih.gov/pubmed/20850201>
5. Portincasa P, Mearin F, Robert M, Plazas MJ, Mas M, Heras J. *[Efficacy
and tolerability of cinitapride in the treatment of functional dyspepsia
and delayed gastric emptying].* *Gastroenterol Hepatol. * *2009* Abstract
<http://www.ncbi.nlm.nih.gov/pubmed/19819042>
6. Robert M, Salvà M, Segarra R, Pavesi M, Esbri R, Roberts D, Golor G. *The
prokinetic cinitapride has no clinically relevant pharmacokinetic
interaction and effect on QT during coadministration with
ketoconazole.* *Drug
Metab Dispos. * *2007* Abstract
<http://www.ncbi.nlm.nih.gov/pubmed/17437965>
- I hope this helps!
Best regards from Madrid, Spain.
Clara Fernández López
Tel: 654913452
Abogada. Socia en www.mmmm.es
Monitora LLL, Madrid
www.laligadelaleche.es
*Calendario de reuniones
<http://www.laligadelaleche.es/madrid/calendario_reuniones.htm>*
*¿Cómo colaborar? <http://www.laligadelaleche.es/colaborar/index.htm>*
¿Cuál es el objetivo de la educación? Estamos formando niños que sólo son
capaces de aprender lo que ya es conocido? ¿O deberíamos intentar
desarrollar mentes creativas e innovadoras, capaces de descubrir desde la
edad preescolar, durante toda la vida? Jean Piaget
Desde que soy madre, escucho de continuo que no educo a mis hijos para
defenderse en el mundo real, que es muy duro. Ante esta acusación solo
puedo declararme culpable, es cierto, educo a mis hijos para que sean
constructores de nuevas realidades, más amables. Carmen Ibarlucea, Diez
cuentos del mundo que ayudan a educar(nos)
2018-02-13 22:36 GMT+01:00 Louanne McGhee <
[log in to unmask]>:
> I can not find any info regarding the use of cinitapride while
> breastfeeding. It appears to have similar uses as domperidone. Doctor is
> telling mom of breastfeeding 2 year old to not nurse for two weeks while on
> medication. Brand name Pemix. I am in Oregon, USA. Thanks for any info.
> Have tried infantrisk with no answer at this time. Not in Medications and
> Mother's Milk.
>
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