Dear Lactnet Friends:
Pediatrics. <http://www.ncbi.nlm.nih.gov/pubmed/10545587#> 1999
Nov;104(5):e61.
Weight gain in infants breastfed by mothers who take fluoxetine.
Chambers CD<http://www.ncbi.nlm.nih.gov/pubmed?term=Chambers%20CD%5BAuthor%5D&cauthor=true&cauthor_uid=10545587>
, Anderson PO<http://www.ncbi.nlm.nih.gov/pubmed?term=Anderson%20PO%5BAuthor%5D&cauthor=true&cauthor_uid=10545587>
, Thomas RG<http://www.ncbi.nlm.nih.gov/pubmed?term=Thomas%20RG%5BAuthor%5D&cauthor=true&cauthor_uid=10545587>
, Dick LM<http://www.ncbi.nlm.nih.gov/pubmed?term=Dick%20LM%5BAuthor%5D&cauthor=true&cauthor_uid=10545587>
, Felix RJ<http://www.ncbi.nlm.nih.gov/pubmed?term=Felix%20RJ%5BAuthor%5D&cauthor=true&cauthor_uid=10545587>
, Johnson KA<http://www.ncbi.nlm.nih.gov/pubmed?term=Johnson%20KA%5BAuthor%5D&cauthor=true&cauthor_uid=10545587>
, Jones KL<http://www.ncbi.nlm.nih.gov/pubmed?term=Jones%20KL%5BAuthor%5D&cauthor=true&cauthor_uid=10545587>
.
Source
Departments of Pediatrics, University of California, San Diego, California
92103, USA. [log in to unmask]
Abstract
OBJECTIVE:
Despite the manufacturer's recommendation that fluoxetine not be used by
women while breastfeeding, many women choose to do so. There is little
information available in the literature to suggest that this practice is or
is not safe. The purpose of this study was to examine weight gain in
infants who are breastfed by mothers who take fluoxetine, compared with
weight gain in infants who are breastfed by mothers who do not take any
psychotherapeutic medication. A secondary goal was to assess the frequency
of reported side effects in infants who are breastfed by mothers who take
fluoxetine.
METHODOLOGY:
A retrospective cohort study design was used. Subjects were identified from
an ongoing pregnancy outcome study conducted through the California
Teratogen Information Service and Clinical Research Program. A total of 64
women were interviewed who had taken fluoxetine during a pregnancy between
the 1989 and 1997; 26 of these women breastfed their infants and continued
to take the medication, and 38 breastfed their infants but did not take the
medication. Postnatal weight gain was taken from pediatric records, and the
frequency of side effects was measured by maternal response to the
interview questionnaire.
RESULTS:
Using linear regression analysis, the infants who were breastfed by mothers
taking fluoxetine demonstrated a growth curve significantly below that of
infants who were breastfed by mothers who did not take the drug. The
average deficit in measurements taken between 2 weeks and 6 months of age
was 392 g (95% confidence interval: -5, -780). Using a repeated measures
analysis of covariance for those infants with more than one postnatal
weight measurement available, the difference between the two groups was
similar, approximately 1.2 standard deviations (P =.005). In response to
interview questions regarding side effects, no mother who breastfed her
infant while taking fluoxetine reported any unusual symptoms that could be
attributed to the medication.
CONCLUSIONS:
These data do not suggest that women who breastfeed while taking fluoxetine
are likely to note unusual behavior in their infants that they consider
related to use of the medication. However, although there was no excess of
infants in the fluoxetine group with postnatal weight measurements >2
standard deviations below the mean, these data indicate that breastfeeding
while taking fluoxetine is associated with reduced growth that may be of
clinical importance in situations in which infant weight gain is already of
concern.
warmly,
Nikki Lee RN, BSN, Mother of 2, MS, IBCLC, CCE, CIMI, ANLC, CKC
Author:* Complementary and Alternative Medicine in Breastfeeding Therapy*
www.breastfeedingalwaysbest.com
https://www.facebook.com/nikkileehealth
*Get my FREE webinar series
*
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