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Subject:
From:
Pamela Morrison <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Mon, 21 Jul 2008 14:42:12 +0100
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Dear all

I've recently come across information in a couple of document setting 
out new findings on contraceptive choices for HIV-positive women, (at 
<http://www.infoforhealth.org/pr/m20/NewFindings.pdf>http://www.infoforhealth.org/pr/m20/NewFindings.pdf 
and  http://www.infoforhealth.org/pr/l14/5.shtml#table3

It reads as follows, (refs are set out beneath):

"Hormonal methods that contain only a progestin are appropriate as 
early as six weeks after childbirth. By that time breastfeeding is 
well established (265)   Progestin-only contraceptives include 
certain oral contraceptives, injectables, vaginal rings, implants, 
and the LNG-IUD. Before six weeks small amounts of the hormone would 
be passed to the newborns, who cannot metabolize steroids at that age 
(18) (25) (61).  When the hormones are taken at six weeks or later, 
the small amounts in breastmilk do not appear to harm an infant's 
growth or affect the quantity and quality of breastmilk (227)."
Refs:
18. BASSOL, S., NAVA-HERNANDEZ, M.P., HERNANDEZ-MORALES, C., 
TRUJILLO-MACIAS, A.M., LOPEZ-LOZANO, M.R., and RECIO, R. Effects of 
levonorgestrel implant upon TSH and LH levels in male infants during 
lactation. International Journal of Gynecology and Obstetrics 76(3): 
273-277. Mar. 2002.)
25. BLODE, H., FOIDART, J.M., and HEITHECKER, R. Transfer of 
drospirenone to breastmilk after a single oral administration of 3 mg 
drospirenone + 30 microg ethinylestradiol to healthy lactating women. 
European Journal of Contraception and Reproductive Health Care 6(3): 
167-171. Sep. 2001.
61.  DIAZ, S. Contraceptive implants and lactation. Contraception 
65(1): 39-46. Jan. 2002.
227.  TRUITT, S.T., FRASER, A.B., GRIMES, D.A., GALLO, M.F., and 
SCHULZ, K.F. Hormonal contraception during lactation. Systematic 
review of randomized controlled trials. Contraception 68(4): 233-238. Oct.2003.
265.  WORLD HEALTH ORGANIZATION (WHO). Medical eligibility criteria 
for contraceptive use, 3rd edition. Geneva, WHO, 2004. 186 p. .

My experience is that hormonal contraceptives (even progestin only 
contraceptives) _may_ negatively affect lactation success.  When 
mothers use them, difficulties may be perceptual (fussiness in the 
baby) and/or real (babies experience low weight gain), and these 
problems resolve when mothers subsequently stop using them.  I'm 
especially concerned that when exclusive breastfeeding may be the 
feeding method of choice for babies under 6 months of HIV-positive 
mothers in developing countries (for whom replacement feeding is 
neither safe nor sustainable) that hormonal contraceptives may 
negatively impact mothers' ability to breastfeed exclusively and/or 
for their babies to thrive.

I know that many of the older studies showing that progestin-only 
preparations were done on non-exclusively breastfed babies.   And I 
know that we've discussed oral contraceptives well on LACTNET, and 
the problems that we, as LCs, have seen with them.  The tone of the 
above document is quite authoritative. Do these latest reviews 
reflect new research conducted on babies who have been exclusively 
breastfed, and for the full 6 months?    I'd welcome others' comments 
and thoughts, experiences or references.

Many thanks.

Pamela Morrison IBCLC
Co-coordinator WABA Breastfeeding and HIV Task Force

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