SThe possible connection between phytoestrogens, milk and coronary heart
disease.
Med Hypotheses 1982 Apr;8(4):349-54 (ISSN: 0306-9877)
Seely S [Find other articles with this Author]
Phytoestrogens are estrogen mimics produced mainly by leguminous plants,
like clover, lucerne and soya beans, but also by some grasses and other
plants. They are isoflavones and other plant phenols, bearing no resemblance
to natural estrogens, but somewhat similar to non-steroidal synthetic
estrogens, like diethylstilbestrol. Normally they have little ill effect on
herbivores, but in large doses they can result in prolonged periods of
estrus. It is suggested that when consumed by lactating cows, the estrogenic
substance appears in their milk and transferred to the human consumer, on
whom the effect could be similar to that of diethylstilbestrol - a substance
with well substantiated atherogenic properties. This could be the
explanation of the strong positive correlation between the consumption of
mild and mortality from coronary disease reported in previous papers of the
writer and other authors, and also of the differences between male and
female mortality from coronary disease. When phytoestrogens are consumed
directly in plants like soya beans, they appear to be correlated with
cerebrovascular disease.
Connection: close
:Possible connection between milk and coronary heart disease: the calcium
hypothesis.
Med Hypotheses 2000 May;54(5):701-3 (ISSN: 0306-9877)
Seely S [Find other articles with this Author]
Sale, Cheshire, UK.
Excessive milk consumption may adversely affect the circulation on account
of the high calcium content of milk and because lactose promotes the
intestinal absorption of calcium. Excessive calcium intake may cause
calcification and rigidification of the large elastic arteries, which could
be an important factor in causing myocardial ischaemia.The calcium
hypothesis can throw light on some puzzling peculiarities of arterial
disease, for instance the changing ratio of male and female mortality rates
in various age groups, the apparently beneficial effect of a warm
environment and the entirely different worldwide distribution of coronary
heart disease and strokes. Copyright 2000 Harcourt Publishers Ltd.
:Influence of milk source on serum lipids and lipoproteins during the first
year of life, Bogalusa heart study.
Am J Clin Nutr 1982 Jan;35(1):42-9 (ISSN: 0002-9165)
Farris RP; Frank GC; Webber LS; Srinivasan SR; Berenson GS [Find other
articles with these Authors]
An epidemiological study of coronary heart disease risk factor variables in
a cohort of 440 infants from birth to age 4 was conducted in Bogalusa, LA.
This report evaluates differences in serum lipids and lipoproteins and
dietary intakes of infants fed various milk or formula types during the 1st
year of life. There were significant positive correlations between serum
total cholesterol and beta-lipoprotein cholesterol levels and consumption of
cow's milk at 6 months of age. The cow's milk-fed infants at 6 months had
significantly greater intakes of animal protein and saturated fat as
compared to the formula-fed groups. At 1 yr these differences were not
found, possibly because of the heterogeneity of the eating patterns of
infants by this age. Serum lipid and lipoprotein levels appear to be
responsive to concurrent dietary intake of fat and cholesterol in
6-month-old infants.
J Dairy Sci 1983 Jul;66(7):1419-35 (ISSN: 0022-0302)
The theory that consumption of homogenized milk containing active xanthine
oxidase is a causative factor in development of atherosclerosis is reviewed.
Biologically available xanthine oxidase in consumed milk products may be
absorbed in the small intestine and enter the blood stream. However, there
appears to be no unequivocal evidence that the absorbed enzyme has any
pathological effects that may contribute to development of atherosclerotic
heart disease.
Include in Document # 6 of 200 from MEDLINE
selection list. Relevance to Query:
Maximum Relevance:Congenital heart disease and cow's milk intolerance.
Helv Paediatr Acta 1984 Aug;39(3):269-74 (ISSN: 0018-022X)
Ventura A; Canciani GP; Tamburlini G [Find other articles with these
Authors]
Four infants with congenital heart disease showed in their first months of
life poor weight gain in spite of the absence of cardiac failure; a
diagnosis of intolerance to cow's milk proteins was made on the basis of
laboratory findings and subsequently confirmed by the success of the
avoidance diet and the positivity of the challenge tests; all four children
had previously received nasogastric feeding, and this may represent a
favouring factor for sensitization. Intolerance to cow's milk proteins
should be considered as a possible cofactor for failure to thrive in infants
with congenital heart disease.
Maximum Relevance:Influence of diets containing cow's milk or soy protein
beverage on plasma lipids in children with familial hypercholesterolemia.
J Am Coll Nutr 1992 Jun;11 Suppl:69S-73S (ISSN: 0731-5724)
Jacques H; Laurin D; Moorjani S; Steinke FH; Gagne C; Brun D; Lupien PJ
[Find other articles with these Authors]
Department of Human Nutrition and Consumer Studies, Laval University,
Quebec, Canada.
The present article summarizes the effects of diets containing either cow's
milk or soy protein beverage on plasma lipids and lipoproteins in children
with familial hypercholesterolemia. After a stabilization period of 6 weeks
without any hypolipemic medication, 10 subjects aged 6-12 years were
randomly assigned to either cow's milk or soy protein beverage with
subsequent crossover after a washout period, each of 4 weeks duration.
During the experimental periods, subjects were fed diets containing 20% of
energy as protein, of which 35% was from cow's milk protein or soy protein
isolate, 28% of energy as fat with a
polyunsaturated:monounsaturated:saturated fat ratio of 1:3:3, and less than
200 mg/day of cholesterol. The soy protein beverage, compared to cow's milk,
induced significant reductions in plasma triglycerides and very-low-density
lipoprotein cholesterol, as well as a significant increase in high-density
lipoprotein cholesterol, indicating that consumption of soy protein beverage
may be beneficial for the prevention of coronary heart disease in children
with familial hypercholesterolemia.
:Beware of the cow [letter; comment] [see comments]
Lancet 1989 Oct 21;2(8669):983 (ISSN: 0140-6736)
Turner RW [Find other articles with this Author]
Comment on: Lancet 1989 Aug 19; 2(8660):424-5; Comment in: Lancet 1989 Dec
2; 2(8675):1334
Site Map Your Account Support About Us
:Comparison of intestinal anaphylactic reactions in sensitized mice
challenged with untreated bovine milk and homogenized bovine milk.
Allergy 1990 Jul;45(5):321-6 (ISSN: 0105-4538)
Poulsen OM; Nielsen BR; Basse A; Hau J [Find other articles with these
Authors]
Department of Veterinary Pathology, Royal Veterinary and Agricultural
University, Copenhagen, Denmark.
Outbred NMRI mice were sensitized for high IgE production either by
subcutaneous injections of low doses of untreated bovine milk or homogenized
bovine milk in combination with intraperitoneal injections of Freund's
Complete Adjuvant or by oral administration of untreated or homogenized
bovine milk without adjuvant. When analysed in murine passive cutaneous
anaphylaxis test both types of milk resulted in production of reaginic
antibodies against bovine milk proteins when given subcutaneously. When
given orally, homogenized milk resulted in reagin production in 10 out of 14
mice, whereas untreated milk resulted in reagin production in only one out
of 12 mice. The sensitized mice, and control mice, were orally challenged
with either untreated milk, homogenized milk or 0.9% NaCl. Examination of
the intestines 40 min after oral administration revealed that homogenized
milk, contrary to untreated milk or 0.9% NaCl, resulted in a large increase
in the mass of the proximal gut segment of mice sensitized orally with
homogenized milk compared with control mice orally challenged with saline (P
less than 0.001), and only mice both sensitized and challenged orally with
homogenized milk showed degranulation of mast cells in the intestinal wall.
By contrast, subcutaneously sensitized mice or mice sensitized orally with
untreated bovine milk showed no significant intestinal reaction upon oral
challenge with either homogenized or untreated bovine milk. These
observations may indicate that the route of sensitization is of great
importance when intestinal reactions are to be studied, and that
homogenization of bovine milk may render the milk more aggressive with
respect to its ability to induce intestinal reactions. The study indicates
that mice may be an attractive experimental animal model for mimicking the
intestinal anaphylactic reactions of cow milk-allergic humans.
[Xanthine oxidase in homogenized cow's milk and Oster's hypothesis: a
review]
[Xanthinoxidase in homogenisierter Kuhmilch und Hypothese von Oster: eine
Ubersicht.]
Z Ernahrungswiss 1983 Dec;22(4):219-33 (ISSN: 0044-264X)
Sieber R [Find other articles with this Author]
Oster has postulated that the enzyme xanthine oxidase in homogenized cow's
milk is the cause of myocardial infarction and angina pectoris. This enzyme
may be absorbed by ingestion, especially of the small particles of the fat
globules, and then carried by lymph streams to the arterial vascular system,
where it is deposited into the myocardium. Then it destroys the aldehydes
liberated from the cell membrane-based plasmalogens. This results in the
intimal damage to the cell membranes of the arterial intima and the
myocardium and ultimately in the development of typical atherosclerotic
lesions in the arteries. The presented review is a critical approach to this
hypothesis. The following factors are discussed: - the influence of
conditions prevailing in the intestine and the stomach on the activity of
the xanthine oxidase in milk, - the possibility of this enzyme being
absorbed in the intestine, - the formation of antibodies against absorbed
xanthine oxidase and - the behaviour of xanthine oxidase administered
intravenously. Compared with present knowledge, this theory gives little
evidence only.
Milk consumption, lactose and copper in the aetiology of ischaemic heart
disease.
Med Hypotheses 1988 Feb;25(2):99-101 (ISSN: 0306-9877)
Strain JJ [Find other articles with this Author]
Biomedical Sciences Research Centre, University of Ulster at Jordanstown,
Newtownabbey, Co, Antrim, Northern Ireland.
Milk is a poor source of copper--a nutrient which is known to be limiting or
marginal in many western diets. Lactose (a major nutritional constituent of
milk) may interfere with copper utilization in milk and in the overall diet.
It is postulated that the strong association between the consumption of milk
and dairy products (especially fresh milk and non-fermented milk products)
and the incidence of ischaemic heart disease (IHD) indicates a central role
for a dietary copper deficiency in the aetiology of this disease.
--Chris Hafner-Eaton, PhD, MPH, CHES, IBCLC [log in to unmask]
€€€INFANT CUISINE AND MOTHER CARE: LACTATION CONSULTING & PERINATAL CARE€€€
***********************************************
The LACTNET mailing list is powered by L-Soft's renowned
LISTSERV(R) list management software together with L-Soft's LSMTP(TM)
mailer for lightning fast mail delivery. For more information, go to:
http://www.lsoft.com/LISTSERV-powered.html
|
