I have a friend who recently was precribed Serzone for depression.  Lacking
Internet access, she asked me to research the drug for her, and this is what I
found.  Please note that the *** emphases are mine, not from the monograph.

~~~~~~~~~~
Nefazodone (Serzone/Bristol-Myers Squibb) is a serotonin reuptake inhibitor
structurally related to trazodone. The drug also appears to block postsynaptic
serotonin receptors. In comparative studies of patients with major depression,
nefazodone proved more effective than placebo and better tolerated than
imipramine. It has little effect on hemodynamics and is less sedating than other
antidepressants.

Nefazodone has some interesting effects: it raises oral temperature, causes a
***dose-related increase in prolactin levels***, increases REM sleep, and has
shown analgesic activity (it may be a useful adjunct in pain management).

Although nefazodone is nonsedating and does not appear to potentiate the
depressant effects of alcohol, the drug interacts with certain benzo-diazepines
(e.g., triazolam, Halcion/Upjohn). (Frewer LJ, Lader M. Int Clin Psychopharmacol.
1993; 8:13-20. Walsh AE et al. Biol Psychiatr. 1993; 33: 115-119.)
~~~~~~~~~~

Additionally, she was told that Serzone would not cause sexual dysfunction, so if
it won't prevent orgasm, perhaps it also won't inhibit let down?   Given some of
the recent discussions about SSRI's and let down, I thought this might be
interesting to the list.

Debbie McCallister
Louisville, KY
Non-professional lurker & breastfeeding busybody

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