An interesting patent from 1981 called "Stabilized, dilute aqueous
preparation of 1.alpha, 25-dihydroxycholecalciferol for neonatal administration" by
Conway et al and assigned to Abbott.  Infant formula is just a sea of changing
nutrition because the previous formulation creates some health hazard.  Here we
have a substance that is made to correct the health problem of high phosphate
load in infant formula.
Valerie W. McClain, IBCLC

http://www.uspto.gov/patft/index.html
patent # 4308264


"Low serum ionized calcium level is associated with serious signs including
seizures, apnea, vomiting, neuromuscular irritability, gastric atony, cyanosis
and lethargy. Hypocalcemia can also occur without signs of neuromuscular
hyperirritability. Correlation of clinical signs with serum calcium levels has been
difficult because of the many clinical variables coexistant with hypocalcemia
in these high risk infants.

Late neonatal hypocalcemia usually occurs in full term or premature infants
who have been started on feedings and who show signs or symptoms of
hypocalcemia only after several days or weeks of feedings. The hypocalcemia appears to be
precipitated by the high phosphate load of most feedings other than human
milk. The high phosphate serum concentration in serum of infants in the first few
weeks is associated with low parathyroid hormone levels and with a low
glomerular filtration rate.

Clinical manifestations of late neonatal hypocalcemia are similar to those
described above in connection with early neonatal hypocalcemia. An
electrocardiographic sign, prolonged QT interval, can also be present. "




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