LACTNET Archives

Lactation Information and Discussion

LACTNET@COMMUNITY.LSOFT.COM

Options: Use Forum View

Use Monospaced Font
Show Text Part by Default
Show All Mail Headers

Message: [<< First] [< Prev] [Next >] [Last >>]
Topic: [<< First] [< Prev] [Next >] [Last >>]
Author: [<< First] [< Prev] [Next >] [Last >>]

Print Reply
Subject:
From:
"Jayne R. Charlamb" <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Thu, 31 Mar 2005 19:04:10 -0500
Content-Type:
text/plain
Parts/Attachments:
text/plain (46 lines)
Diane wrote: "I'm puzzled by the combination of short half-life and
possibility that
the drug can linger, so that new pregnancies aren't recommended for
several *months*.  What's the pharmacology there?  Is it a lingering
metabolite that's the concern?"

Diane- I believe that new pregnancies are not recommended for several months
after MTX based on findings in an *old* study (from the late 1970's I think)
of a group of women treated with MTX for molar pregnancies.  It showed an
increased risk of fetal abnormalities in new pregnancies for several months
after the molar pregnancy in women who had received the drug compared to
those who had not.  I don't remember the details of the study (how well it
was controlled, etc), but I can try to find it if you are interested.  I
also don't know what the theory was regarding the underlying cause of the
malformations (lingering metaolite or otherwise).

Also- forgetting about the MTX, I'm not sure of the data supporting this,
but many in the medical community tout that the sooner a woman attempts
pregnancy after an ectopic, the more likely she is to have suffer another
ectopic.  Hence it is often recommended that a woman who has had an ectopic
wait a few months before trying to get pregnant again.  (And in the case of
a molar pregnancy, a woman is strongly advised to wait a full year before
becomming pregnant again so that her hormone levels (hcg) can be adequately
followed to ensure that the mole is not growing back-- if she gets pregnant
with a new pregnancy, her hcg would go up, but we wouldn't know if it was
appropriately elevated from the new pregnancy or if the molar tissue was
growing as well.)

Hope that helps somewhat, though I realize I didn't really answer your
question.

Jayne Charlamb, MD
Syracuse, NY

             ***********************************************

To temporarily stop your subscription: set lactnet nomail
To start it again: set lactnet mail (or digest)
To unsubscribe: unsubscribe lactnet
All commands go to [log in to unmask]

The LACTNET mailing list is powered by L-Soft's renowned
LISTSERV(R) list management software together with L-Soft's LSMTP(R)
mailer for lightning fast mail delivery. For more information, go to:
http://www.lsoft.com/LISTSERV-powered.html

ATOM RSS1 RSS2