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Subject:
From:
Nikki Lee <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Tue, 19 Oct 2010 09:39:48 -0400
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 Glycation products in infant formulas: chemical, analytical and
physiological aspects.

Pischetsrieder M<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Pischetsrieder%20M%22%5BAuthor%5D>
, Henle T<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Henle%20T%22%5BAuthor%5D>
.

Department of Chemistry and Pharmacy, Emil-Fischer-Center, University of
Erlangen-Nuremberg, Schuhstr. 19, 91052, Erlangen, Germany,
[log in to unmask]
 Abstract

Infant formulas are milk-based products, which are adapted to the
composition of human milk. To ensure microbiological safety and long shelf
life, infant formulas usually undergo rigid heat treatment. As a consequence
of the special composition and the heat regimen, infant formulas are more
prone to thermally induced degradation reactions than regular milk products.
Degradation reactions observed during milk processing comprise lactosylation
yielding the Amadori product lactulosyllysine, the formation of advanced
glycation end products (AGEs), and protein-free sugar degradation products,
as well as protein or lipid oxidation. Several methods have been developed
to estimate the heat impact applied during the manufacturing of infant
formulas, including indirect methods such as fluorescence analysis as well
as the analysis of defined reaction products. Most studies confirm a higher
degree of damage in infant formulas compared to regular milk products.
Differences between various types of infant formulas, such as liquid,
powdered or hypoallergenic formulas depend on the analyzed markers and
brands. A considerable portion of protein degradation products in infant
formulas can be avoided when process parameters and the quality of the
ingredients are carefully controlled. The nutritional consequences of
thermal degradation products in infant formulas are largely unknown.

-- 
Nikki Lee RN, BSN, Mother of 2, MS, IBCLC, CCE, CIMI
craniosacral therapy practitioner
www.breastfeedingalwaysbest.com

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