I found good information on mifepristone (one of two components in RU-486)
on the web, but need help interpreting it.  Here are excerpts:

*molecular weight 430

*protein binding 98%

*bioavailability 69%

*peak concentration 90 minutes

*Following a distribution phase, elimination of mifepristone is slow at
first (50% eliminated between 12 and 72 hours) and then becomes more rapid
with a terminal elimination half-life of 18 hours.

That last sentence doesn't mean much to me.  My best guess is that the first
half-life takes anywhere from 12 to 72 hours, but is 18 hours for each
half-life thereafter.  Can anyone interpret it for sure and get an overall
sense of how seriously we need to take this drug, assuming a baby of 7
months?

The website from which I got the information was
http://www.fda.gov/cder/foi/nda/2000/20687_mifepristone.htm

--
Diane Wiessinger, MS, IBCLC  Ithaca, NY
www.wiessinger.baka.com

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