I never heard of this one before.  Here is what Hale says:

"Antidepressant with a structure unrelated to tricyclics.  One report in
the literature indicates that bupropion probably accumulates in human
milk.  Following on 100 mg dose in a mother the milk:plasma ratio ranged
from 2.51 to 8.58, clearly suggesting a concentrating mechanism for this
drug in human milk.  However, plasma levels of bupropion (or its
metabolites) in the infant were undetectable, indicating that
accumulation in infant plasma apparently did not occur under these
conditions (infant was fed 7.5 to 9.5 hours after dosing)."

I left out some information.  There are some concerns but on the other
hand the baby would only get small amounts. On the other hand, this is
one case report and the baby was breastfed only 2 times daily.

Is there any reason this mother needs *this* antidepressant?  What about
sertraline (Zoloft), or paroxetine (Paxil)?

Jack Newman, MD, FRCPC