Re:  Benefits of adding nucleotides to formula

The following information is excerpted from a research update presentation
given last year.   Formula company scientists presented their work at a
pediatric nutrition conference in the Texas Medical Center shortly before my
presentation - not all of the work was published at the time.

( NT refers to nucleotide)
Published references:
JD Carver, B Pimentel, WI Cox and LA Barness.  Dietary nucleotide effects
upon immune function in infants. Pediatrics 1991. 88(2): 359-363.
... Increased natural killer cell % toxicity was higher for HM and NT+ form
than for control formula (41.7 +/- 4.7, 32.2 +/- 3.4, 21.7 +/- 2.2,
respectively).

Martinez-Augustin et al. Dietary nucleotides might influence the humoral
immune response against cow's milk proteins in preterm neonates.  Biol
Neonate. 1997;7:215-23.
...Serum IgG antibody to B-lactoglobulin were higher in preterm infants fed
an NT-supplemented formula cf control formula

Kuo-Inn Tsou Yau et al. Effect of Nucleotides on Diarrhea and Immune
Responses in Healthy Term Infants in Taiwan. JPGN 2003; 36:37-43
...Increased SIgA, trend toward less diarrhea, increased upper resp. tract
infections,similar antibody response to hepatitis B vaccination cf Control
formula

Ostrom KM, Cordle CT, Schaller JP, Winship TR, Thomas DJ, Jacobs JR, Blatter
MM,
Cho S, Gooch WM 3rd, Granoff DM, Faden H, Pickering LK. Immune status of
infants fed soy-based formulas with or without added
nucleotides for 1 year: part 1: vaccine responses, and morbidity.  J Pediatr
Gastroenterol Nutr.  2002 Feb;34(2):137-44.

Pickering LK, Granoff DM, Erickson JR, Masor ML, Cordle CT, Schaller JP,
Winship
TR, Paule CL, Hilty MD. Modulation of the immune system by human milk and
infant formula containing
nucleotides.  Pediatrics.  1998 Feb;101(2):242-9.


Oucome comparisons including references unpublished at the time:

Stool bacteria:
* Gil et al -  NT formula = stool microbes closer to HM fed
* Balmer et al - opposite effect

Diarrhea:
* Brunser, 1994
* NT form = lower risk of diarrhea than non-NT

* Pickering
* NT form + BF group = lower risk of diarrhea

* Ostrom
* NT soy form and non-NT soy = higher risk of diarrhea than BF

* Kuo-Inn Tsou Yau
* NT form = lower risk of diarrhea than non-NT

Definitions of breastfeeding in Pickering and Ostrum studies:
At least 2 months exclusive.  Then moms could add non-NT formulas.

NOTE:  The definition of breastfeeding is important since less than 3 months
exclusivity is not generally associated with reduced long term illness.
Therefore saying the NT supplemented formulas were comparable to human milk
is somewhat misleading.  When I asked why not select a human milk fed group
that breastfed for at least 3 months exclusively as a comparison group (and
therefore would have a statistically lower risk of diarrhea than formula fed
infants) the response was that it was difficult to find mothers who
breastfed exclusively for long enough to qualify.

             ***********************************************

To temporarily stop your subscription: set lactnet nomail
To start it again: set lactnet mail (or digest)
To unsubscribe: unsubscribe lactnet
All commands go to [log in to unmask]

The LACTNET mailing list is powered by L-Soft's renowned
LISTSERV(R) list management software together with L-Soft's LSMTP(R)
mailer for lightning fast mail delivery. For more information, go to:
http://www.lsoft.com/LISTSERV-powered.html