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Subject:
From:
"Valerie W, McClain" <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Sat, 29 Nov 2003 07:03:27 EST
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I believe I have posted this patent before but I was just rereading it and
noticed something interesting.  This patent is called "Dietary compositions and
methods using bile salt-activated lipase."  The inventors are Tang et al. and
it was filed in 1987.  This patent got their milk from the Oregon Health
Science Center.  Interesting that just a few months ago we had a Lactnet discussion
about donating human milk to this particular institution's primate lab.
Another interesting coincidence is that it was Dr. Paul Lewis, director of the
pediatric HIV clinic, at this same university who testified against Kathleen
Tyson (hiv positive mother who was denied the right to breastfeed her infant).
Rather fascinating...
Valerie W. McClain, IBCLC


http://www.uspto.gov/patft/index.html
patent # 4944944


Although it has not been confirmed, it is believed that in human infants and
particularly in premature infants, pancreatic development and therefore enzyme
production is incomplete at birth. The presence of BAL in human milk is
thought to be a compensatory mechanism for the infant's immature pancreatic
function. However, many human infants are not breast fed, and the most common infant
formula comprises cow's milk which does not contain milk BAL.

Thus, the present invention provides an improved method for feeding infants.
A dietary base from a first source and comprising fats is administered to the
infant. The base preferably comprises cow's milk or a prepared infant formula
comprising cow's milk. However, if necessary, a milk-free formula with the
necessary fats may be employed.

BAL from a second source also is administered to the infant in an amount
sufficient to improve the infant's digestion of fats in the formula, and most
preferably at the rate of about 1 mg per 200 mg fat in the base. Preferably, the
BAL is obtained from the same species as the infant, so that human BAL,
preferably milk BAL, is given to human infants. The BAL may be administered with the
base or shortly before or after it.

EXAMPLES

1. MILK BILE SALT-ACTIVATED LIPASE ACTIVITY STUDIES OF HUMAN AND CAT MILK

Recently Freed, et al. reported the presence of bile salt-activated lipase in
the milk of cats and dogs. [Biochim. Biophys. Acta, 878:209-215 (1986)]. We
performed studies to confirm this.

Cat milk was obtained from 4 common cats. The milk was expressed using a
device similar to that described by McKenzie and Anderson [J. Dairy Sci.,
62:1469-1470 (1979)] for milking small animals. Samples of fifteen day post partum
human milk was obtained from Oregon Health Science Center (Portland, Oreg.) and
shipped in dry ice.




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