Wise Ones,
I need help from anyone savvy on changing different calculations to common
terms. I know I can do it, but it’s painful, so if any Lactnetter loves
math and would like to help me out, I really appreciate it. Conversely, if I
don’t hear from anyone, I will figure it out (painfully) and let you all
know :-) I have read the archives on this subject and not found this
specific explanation.
This has to do with the Depo Provera shot before d/c. The physician has
asked me what the pregnancy progesterone levels are, and *how much* do they
drop, compared to the DP shot. I have found on the internet that pregnancy
levels appear to peak at a mean of 166.2 ng/ml (+/- SD).
http://repro-med.net/papers/progest.php The progesterone levels drop
precipitously to non-pregnancy levels within 72 hours.
The DP shot appears to be given as a 150 mg dose good for 3 months
http://www.pfizer.com/download/ppb_depo_provera_contraceptive.pdf. Normal,
non-pregnancy progesterone levels seem to range from 8-10 ng/ml midluteal
phase, but can go up to 20 ng/ml
http://www.parentsplace.com/expert/obgyn/qas/0,,166297_113610,00.html
If I am doing my math correctly, and 1 ng = one billionth of a gram, and 1
mg = one-thousandth of a gram, then the DP is a humongous flood of
progesterone, far higher than the human body would ever normally have, even
during pregnancy. The piece I am missing, is, is the shot 150 mg/ml or 150
mg of something else?
I am preparing several studies to help him decide whether or not to continue
to give it before d/c, including the manufacturer's insert saying to wait 6
weeks pp, Kennedy, Short & Tully, 97 article, the list from the new Riordan
HL of the health organizations that rec waiting (WHO, IPPF, and TGWG) and
Hannon's 1997 study showing it doesn't make a difference, to be fair and
honest that there is disagreement among researchers. Also including info
from Hale rec waiting or using progestin only pills, because they are a much
lower dose.
Thanks to anyone who likes to do these kinds of calcs. I need this before
Monday:-)
Anna Swisher, MBA, IBCLC
Abundant Blessings
Austin, TX
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