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Subject:
From:
Kathleen Bruce <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Tue, 4 Jun 1996 07:36:05 -0400
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Barb asked about Capoten...and Dilantin. It seems that someone in your
facility could really benefit by having in-house UP TO DATE information
regarding drugs in breastmilk. There are several available...and I quote
from....

From Tom Hale's book....1995, p. 62, "Capoten, generic name Captopril,
antihypertensive drug (ACE inhibitor). Small amounts secreted (4.7
micrograms/L milk...I think it is Micrograms..it is Mug/L)  In one report of
12 women treated with 100 mg three times daily, maternal serum levels
averaged 713 mug/l, while milk levels averaged 4.7 mug/L at 3.8 hours after
admin.  Manufacturer's literature indicates that milk levels are
approximately 1 % of maternal blood levels. No adverse effects have been
reported thus far. No effects have been found in nursing infants. Use only
if detrmined to be important to mother's health Obseve for hypotension,
decreased urine output and seizures. AAP Compatible with Breastfeeding.
AHL=2.2 hours, M/P= 0.012, PB= 30%, PK= 1 hour."

Dilantin is also considered AAP compatible with bf..."small amounts secreted
into breastmilk. Effect on infant is minimal if levels in maternal
circulation kept in low-normal range (10 mug/mL) Peaks in milk at 3/5 hours.
Phenytoin levels in milk have been reported to be as high as 7.2% of
maternal dose. Compatible with bf if mother and infant closely monitored.
Observe infant for sedation and decreased suckling reflex. AAP Compatible
with bf."

I do not see the reason for binding this poor mother's breasts, and ruining
her chances of breastfeeding during this difficult time in her life.

Kathleen

Kathleen B. Bruce, BSN, IBCLC co-owner Lactnet (In Vermont)
LACTNET WWW site: http://www.mcs.com/~auerbach/lactation.html
LACTNET archives http://library.ummed.edu/lsv/archives/lactnet.html

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