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Subject:
From:
Nikki Lee <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Sat, 9 Jun 2012 14:10:11 -0400
Content-Type:
text/plain
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Dear Lactnet Friends:

Oh how I wish 10% of the money spent to duplicate evolution was spent to
support breastfeeding!!

Huge assumption: studying babies for 4 months gives enough information
about the health of the rest of their lives.


Nutr J. <http://www.ncbi.nlm.nih.gov/pubmed/22676715#> 2012 Jun 7;11(1):38.
[Epub ahead of print]
Growth and tolerance of infants fed formula supplemented with polydextrose
(PDX) and/or galactooligosaccharides (GOS): double-blind, randomized,
controlled trial.
Ashley C<http://www.ncbi.nlm.nih.gov/pubmed?term=Ashley%20C%5BAuthor%5D&cauthor=true&cauthor_uid=22676715>
, Johnston WH<http://www.ncbi.nlm.nih.gov/pubmed?term=Johnston%20WH%5BAuthor%5D&cauthor=true&cauthor_uid=22676715>
, Harris CL<http://www.ncbi.nlm.nih.gov/pubmed?term=Harris%20CL%5BAuthor%5D&cauthor=true&cauthor_uid=22676715>
, Stolz SI<http://www.ncbi.nlm.nih.gov/pubmed?term=Stolz%20SI%5BAuthor%5D&cauthor=true&cauthor_uid=22676715>
, Wampler JL<http://www.ncbi.nlm.nih.gov/pubmed?term=Wampler%20JL%5BAuthor%5D&cauthor=true&cauthor_uid=22676715>
, Berseth CL<http://www.ncbi.nlm.nih.gov/pubmed?term=Berseth%20CL%5BAuthor%5D&cauthor=true&cauthor_uid=22676715>
.
 Abstract

ABSTRACT:
BACKGROUND:

To ensure the suitability of an infant formula as the sole source of
nutrition or provide benefits similar to outcomes in breastfed infants,
advancements in formula composition are warranted as more research
detailing the nutrient composition of human milk becomes available. This
study was designed to evaluate growth and tolerance in healthy infants who
received one of two investigational cow's milk-based formulas with
adjustments in carbohydrate, fat, and calcium content and supplemented with
a prebiotic blend of polydextrose (PDX) and galactooligosaccharides (GOS)
or GOS alone.


METHODS:

In this multi-center, double-blind, parallel-designed, gender-stratified
prospective study 419 infants were randomized and consumed either a
marketed routine cow's milk-based infant formula (Control; Enfamil(R)
LIPIL(R), Mead Johnson Nutrition, Evansville, IN) (n = 142) or one of two
investigational formulas from 14 to 120 days of age. Investigational
formulas were supplemented with 4 g/L (1:1 ratio) of a prebiotic blend of
PDX and GOS (PDX/GOS; n = 139) or 4 g/L of GOS alone (GOS; n = 138).
Anthropometric measurements were taken at 14, 30, 60, 90, and 120 days of
age. Daily recall of formula intake, tolerance, and stool characteristics
was collected during study weeks 1 and 2 and 24-h recall was collected at
60, 90, and 120 days of age. Medically-confirmed adverse events were
recorded throughout the study.


RESULTS:

There were no group differences in growth rate from 14 to 120 days of age.
Discontinuation rates were not significantly different among study groups.
No differences in formula intake or infant fussiness or gassiness were
observed. During study weeks 1 and 2 and at 60 days of age stool
consistency ratings were higher (i.e. softer stools) for infants in the
PDX/GOS and GOS groups versus Control and remained higher at 120 days for
the PDX/GOS group (all P < 0.05). The overall incidence of
medically-confirmed adverse events was similar among groups.


CONCLUSIONS:

Investigational routine infant formulas supplemented with 4 g/L of either a
prebiotic blend of PDX and GOS or GOS alone were well-tolerated and
supported normal growth. Compared to infants who received the
unsupplemented control formula, infants who received prebiotic
supplementation experienced a softer stooling pattern similar to that
reported in breastfed infants. Trial registration ClinicalTrials.gov
Identifier: NCT00712608.

warmly,

Nikki Lee RN, BSN, Mother of 2, MS, IBCLC, CCE, CIMI, ANLC, CKC
craniosacral therapy practitioner
www.breastfeedingalwaysbest.com

             ***********************************************

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