Dear Liz:

Avastin used as an ocular injection is discussed in this reassuring post
in the Medications Forums from Hale's website (where I found it for a
client of mine).

http://66.230.33.248/discus/messages/41/8003.html?1189460617

(The Forums can be a useful resource, particularly on newer or less
common drugs.)

It is a monoclonal antibody, used in large doses for cancer treatments,
and in that context, there are warnings against breastfeeding while in
treatment.

But Hale points out that the molecular size would make it unlikely to
transfer into milk.  But he's even more reassuring about the lack of
transfer from a small quantity injected directly into the eye's vitreous
fluid to treat a local problem.  Another doctor also wrote in to discuss
the blood/ocular barrier that would make transfer even less likely.

Sealing a retinal flaw with a laser (which I had done for a
histoplasmosis spot, at age 16, so the technology may have improved in
the intervening eon) does leave a blind spot, which the eye compensates
for in normal use.

Margaret Sabo Wills, LLLL, IBCLC, Maryland

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