It may be possible to maintain reasonable blood levels with infrequent
dosages. But unfortunately, Candida seems to be becoming much more resistant
to fluconazole. Five years ago, I treated mothers with 100 mg once daily for
10 days. Almost all were cured and relapse was uncommon. Now, even with
undoubted Candida infection, and treating with 400 mg loading and 200 mg
daily until pain is gone for a week, many women (perhaps 25-40%) do not
respond well or relapse frequently.

Larger doses and more frequent dosing, as above, will give higher blood
levels more quickly.  The infrequent dosaging is a loser approach, in my
opinion. One reason why so much resistance seems to be occuring is the one
dose treatment for vaginal yeast.

Jack Newman, MD, FRCPC