I have had a number of emails about the new formula from Mead Johnson, 
Enfamil RestFull. The new formula RestFull from Mead Johnson is the 
exact same formulation as Enfamil AR. I called Mead Johnson and they 
confirmed that this is simply the same formula with a different label 
and indication for use. Enfamil AR is for reflux and has added rice 
starch which of course RestFull does too.

My concern stems from a number of issues, especially that of the 
possibility of increasing the risk for SIDS. When I asked Mead Johnson 
if studies had looked at this possibility, the answer was that they had 
not.

There has been much research done on adding ingredients to infant 
formula to make AM and PM feedings, specifically by adding tryptophan 
to infant formula. Tryptophan functions as a biochemical precursor for 
serotonin (a neurotransmitter), synthesized via tryptophan hydroxylase. 
Serotonin, in turn, can be converted to melatonin, both of which affect 
sleep-wake rhythms and act as a mild sedative. Other research looked at 
adding alpha-lactalbumin to formula because it has a high concentration 
of tryptophan and infants fed these experimental formulations fell 
asleep faster and stayed asleep longer than those infants without the 
added alpha-lactalbumin in their feedings.

I would direct complaints to the FDA, asking about the safety of 
inducing sleep in infants during the high risk period for SIDS.

Marsha Walker, RN, IBCLC
Weston, MA

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