Might anyone have access to this article? It is in Japanese but contains
some potentially very important information.

Nippon Sanka Fujinka Gakkai Zasshi. 1986 Sep;38(9):1605-12.

[Comprehensive approach to the clinical study of the administration of
dehydroepiandrosterone-sulfate (DHA-S) during the induction of labor]
[Article in Japanese]

Aisaka K, Ando S, Kokubo K, Sasaki S, Yoshida K.

Effects of Dehydroepiandrosterone-Sulfate (DHA-S) administration during the
induction of labor were analysed comprehensively in 116 cases of primipara
without any complications. In all of the patients delivery was induced by
means of intravenous drip infusion of oxytocin. DHA-S was given as follows;
Group A: no administration of DHA-S, Group B: intravenous drip infusion of
600 mg of DHA-S, Group C: intravenous injection of 200 mg of DHA-S every two
hours (max, five times). The duration of the first and second stages of
labor was reduced significantly in Group C compared to that of Group A (p
less than 0.02). Serum DHA-S and estradiol levels in the patients in Groups
B and C were significantly higher than those in Group A during the induction
of the labor (p less than 0.05-0.005). The secretion of maternal milk was
suppressed transiently by the administration of DHA-S (p less than
0.05-0.005), and there was a significant negative correlation between the
total amount of maternal milk secretion and the total dose of DHA-S (r =
-0.6320, p less than 0.005). Maternal serum prolactin levels did not change
significantly following the administration of DHA-S, but estradiol increased
significantly following the administration of DHA-S until 48 hours after
delivery. These facts suggested that the intravenous injection of 200mg of
DHA-S every two hours was effective in assisting the induction of labor, and
the transient suppression of maternal milk secretion due to the
administration of DHA-S might be caused by the high level of maternal serum
estradiol which was converted from DHA-S in the placenta.

~Lisa Marasco

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