Dear Kathy

Datas about ceftizozime
31-38% protein bound
plasmatic half live : 1,1-2,3 hours
volume of distribution : 0,5 l/kg
pediatric dose : 50 mg every 6 to 8 hours

After injection of 1g of ceftozoxime in mothers, maximal level in milk was
0,2 to 0,3 mg/l. Ratio milk/plasma estimated to 0,05. Can be used without
problem in breastfeeding mother.

References :
Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy
1984 ; 5 : 57-60.
Takake Z et al. Clinical and laboratory studies on ceftizoxime in the fields
of obstetrics and gynecology. Chemotherapy 1980 ; 28 (suppl 5) : 863-73.

Kindly
Françoise Railhet
Manager of the LLL France Medical Associates Program
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