Hope you all find this interesting.

Warmly,
Andrea Eastman, MA, CCE, IBCLC
Granville, Ohio
mailto:[log in to unmask]
http://www.geocities.com/HotSprings/8978

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Brown TE, Fernandes PA, Grant LJ, Hutsul JA, McCoshen JA. Effect
of parity on pituitary prolactin response to metoclopramide and
domperidone: implications for the enhancement of lactation. J Soc
Gynecol Investig 2000 Jan-Feb;7(1):65-9

OBJECTIVE: The gastrointestinal motility agents metoclopramide
and domperidone are known to increase pituitary prolactin (PRL)
secretion and breast milk production. This study compared the
effect of single doses of two strengths of metoclopramide and a
single dose of domperidone on PRL secretion.

METHODS: Ten nonpregnant women had baseline evaluation of serum
PRL concentrations. The PRL concentrations were then determined
after random oral administration of metoclopramide 10 mg,
metoclopramide 5 mg, and domperidone 10 mg. Blood samples were
drawn in the first 7 days of the menstrual cycle, at 13 time
points over a 6-hour period (0, 15, 30, 45, 60, 75, 90, 120, 150,
180, 240, 300, and 360 minutes), with the zero time point
beginning at 0800 hours. Variables such as weight, height, age,
gravidity, parity, and oral contraceptive use were recorded.

RESULTS: Baseline PRL concentrations showed the natural circadian
rhythm. Metoclopramide and domperidone both caused a significant
increase in PRL. However, PRL secretion was most influenced by
parity. Nulliparous women had the quickest and highest PRL
secretion with metoclopramide 10 mg, compared with the PRL
response with metoclopramide 5 mg and domperidone 10 mg.
Conversely, multiparous women had PRL secretion patterns that
were equivalent between the medications.

CONCLUSIONS: The PRL response to the medications was most
influenced by parity. Therefore, we suggest that the medication
therapy of choice for enhancing lactation may not be the same in
all women, but may instead be determined by parity.

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