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Subject:
From:
"Catherine Watson Genna, IBCLC" <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Thu, 3 Apr 2003 11:51:45 -0500
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Just came upon this doing a medline search for something else...  It is
a study of language skills in 2 year olds exposed to mercury prenatally.
  There was no effect of duration of bf on either the mercury exposed
group or the control group.  If mercury in breastmilk were causing
learning disabilities, one would expect longer duration of bf to lead to
increased language delay.
The citation and abstract:


Tagum study II: follow-up study at two years of age after prenatal
exposure to mercury.

Ramirez GB, Pagulayan O, Akagi H, Francisco Rivera A, Lee LV, Berroya A,
Vince Cruz MC, Casintahan D.
Pediatrics. 2003 Mar;111(3):e289-95.

Research Development Office, Philippine Children's Medical Center,
Quezon City, Philippines. [log in to unmask]

OBJECTIVES: To correlate the presence and levels of total mercury (THg)
in cord blood and meconium indicating prenatal exposure with
developmental milestones at 2 years and to compare these subjects with
controls of comparable age using cognitive adaptive test and clinical
linguistic auditory milestone scale (CAT/CLAMS). METHODS: In 48 of the
original Tagum (T) subjects, cord blood and meconium Hg levels, head
circumference (HC) at birth, and duration of breastfeeding were
correlated with CAT/CLAMS at 2 years. At 2 years, THg levels using cold
atomic vapor absorption spectrometry were determined in the hair of 46 T
subjects and 88 Saranggani (S) controls; THg levels in blood were tested
in 48 T subjects and 45 S controls. These levels were correlated with
CAT/CLAMS. Both groups had standard physical and neurologic
examinations, hearing screen using transitory evoked otoacoustic
emissions, serum glutamate pyruvate transaminase, and routine
urinalysis. A prevalidated Socioeconomic Means Test was given to both
groups. RESULTS: The Hg level in cord blood was negatively correlated
with CAT/CLAMS at 2 years. The HC at birth was negatively correlated
with levels of Hg in hair of T subjects 2 years later. HC at birth and 2
years hence were positively correlated with CAT/CLAMS. The following
were significantly higher in S controls than in T subjects: expressive
language quotient 82.569 +/- 2.21 versus 71.57 +/- 2.61; CLAMS 87.96 +/-
2.43 versus 77.67 +/- 2.51; CAT 90.57 +/- 2.22 versus 83.15 +/- 1.43;
and full-scale developmental quotient 89.31 +/- 2.14 versus 80.56 +/-
1.86. Fifteen percent of T subjects had global delay (full-scale
developmental quotient <or=70) versus 5.48% in S controls. Hg levels in
hair and blood in both T subjects and S controls at 2 years showed no
correlation with CAT/CLAMS. The duration of breastfeeding in both groups
likewise showed no correlations with CAT/CLAMS. CONCLUSION: The study
suggests that prenatal Hg exposure is correlated with lower scores in
neurodevelopmental screening, but more so in the linguistic pathway.
Other confounding factors cannot be eliminated.
PMID: 12612286 [PubMed - in process]

 From PubMed

--
Catherine Watson Genna, IBCLC  New York City  mailto:[log in to unmask]

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