At 04:33 PM 2/28/98 -0500, you wrote:
>My friend who had to take Flagyl for trichiminosis (sp?) just found out
>that the 24-hour h*** they went through to pump and dump and not nurse her
>10 mo for 24 hrs. did NOT work.

Here is a former post from Tom Hale.

Patricia Gima, IBCLC
Milwaukee
___________________________

>RE:  Metronidazole/flagyl
>
>I just today ran across an interesting article that I have failed to see
>before concerning metronidazole use in breastfeeding women. For those of you
>fighting this battle,  below is good data suggesting it is safe to use in
>breastfeeding moms.
>
>Regards
>Tom Hale, Ph.D.
>-----------------------------------
>
>
>Passmore CM. McElnay JC. Rainey EA. D'Arcy PF. Metronidazole excretion in
>human milk and its effect on the suckling neonate.  British Journal of
>Clinical Pharmacology. 26(1):45-51, 1988 Jul.
>
>Abstract
>1. Milk and plasma metronidazole and hydroxymetronidazole concentrations
>were measured in 12 breast-feeding patients following multiple doses of
>metronidazole (400 mg three times daily). All patients received
>metronidazole in combination with other broad spectrum antibiotics.
>2. Plasma concentrations of both parent drug and metabolite were measured in
>seven suckling infants. Thirty-five infants were monitored for adverse
>reactions to maternal metronidazole therapy and two further groups of
>suckling infants, those whose mothers received either ampicillin alone or no
>drug therapy, were recruited as controls.
>3. The mean milk to plasma ratio (M/P) was 0.9 for metronidazole and 0.76
>for hydroxymetronidazole while the mean milk metronidazole concentrations
>(around Cmax) were 15.5 micrograms ml-1. The mean milk hydroxymetronidazole
>concentration was 5.7 micrograms ml-1.
>4. Infant plasma metronidazole concentrations ranged from 1.27 micrograms
>ml-1 to 2.41 micrograms ml-1, and the corresponding   hydroxymetronidazole
>concentrations from 1.1 to 2.4 micrograms ml-1.
>5. There were no significant increases in adverse effects in infants which
>could be attributable to maternal metronidazole therapy.
>6. Metronidazole was excreted in milk at concentrations which caused no
>serious reactions in the infants studied. The drug may therefore be
>administered at doses of 400 mg three times daily to mothers wishing to
>breast-feed their infants.
>
>
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