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Subject:
From:
Diane Wiessinger <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Tue, 14 Mar 2000 08:23:39 -0400
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Ah, Vermox!  I had a skirmish with it in 1993 (before Tom Hale, who cites
its poor oral absorption and high protein binding).  I tried to get further
information directly from the company and ended up getting a note from
someone at Janssen Research Foundation in Belgium, the body of which was
(quoting):
**
1. The number of women whose milk was tested for mebendazole following a 100
mg oral dose is one.

2. Milk peak concentration of mebendazole was 5.0 ng/ml.  Time after which
mebendazole was no longer detectable in the milk was 13.25 hours in the
patient studied.  High levels of mebendazole in the breast milk are very
unlikely since absorption of mebendazole is limited.

3. The lower limit of detection is less than or equal to 1.0 ng/ml.

4. There is no evidence that mebendazole inhibits the lactation.

5. The patient evaluation was done in Sweden, March 1990.

6.  Mebendazole is used in European dairy cattle.
**
I found the dairy cattle comment especially interesting!

Diane Wiessinger, MS, IBCLC, LLLL  Ithaca, NY

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