According to the 2002 Medications and Mothers Milk:

"Sotalol is a typical beta blocker antihypertensive with low lipid
solubility.  It is secreted in milk in high levels.  Sotalol concentrations
in milk ranged from 4.8 to 20.2 mg/L (mean = 10.5 mg/L) in 5 mothers.  The
mean maternal dose was 433 mg/day.  Although these milk levels appear high,
no evidence of toxicity was noted in 12 infants."

It's lactation risk category is L3 (moderately safe); the pregnancy risk
category is B.

Pediatric concerns:  None reported via milk, but observe for sedation,
bradychardia, hypotension, weakness.  It *is* approved by the AAP for use in
breastfeeding mothers.

Drug interactions:  Decreased effect when used with aluminum salts,
barbituates, calcium salts, cholestyramine, NSAIDs, ampicillin, rifampin,
and salicylates.  Beta blockers may reduce the effect of oral sulfonylureas
(hypoglycemic agents).  Increased toxicity/effect when used with other
antihypertensives, contraceptives, MAO inhibitors, cimetidine and numerous
other products.  See drug interaction reference for complete listing.

Alternatives:  Propranolol, Metoprolol

-- Natalie, mom to James, 1.25.99 and Molly, 5.11.01

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