To : Keitha
Re : Salsalate

Salsalate is a special di-salicylic acid formulation (rarely used),  that
when de-esterified in the gut and plasma,  releases pure salicylic acid into
the plasma compartment.  Salicyclic acid is the de-acetylated form of
aspirin as well.  Salicylic acid transfers poorly into human milk, due to
its polarity.  I think it would be fine for this mom to breastfeed as long
as the infant is normal, and  has good urinary output.  The mom might want
to reduce her dose during the first month of life, until the infant has
established good renal function.

Watch for diarrhea, and other forms of salicylate poisoning, although this
would be very unlikely.


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To : Lyla
Re : hydrocortisone topical, and Elimite(permethrin)

I would not worry about the hydrocortisone, as the absorption through skin
is minimal.  We do not know how much permethrin(Elimite) is absorbed, but
most is instantly metabolized.  Thus I doubt it would pose a real problem to
a breastfed infant.  However, as it is only used for up to 14 hours,  a
brief pumping and dumping(12-14 hours) is not illogical, but probably not
really necessary.


Regards
Tom Hale, Ph.D.
Associate Professor of Pediatrics