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Lactation Information and Discussion <[log in to unmask]>
Date:
Sun, 21 Dec 1997 09:38:06 -0500
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I would not say that the long half life NSAID's are necessarily
contraindicated during breastfeeding.  They all tend to be quite
highly protein bound, and their oral bioavailability tends to be low.
Thus, diclofenac, or ibuprofen are better for nursing mothers because
of their short half lives, but the others have been used without
problems as well.

The thing is that there is not much to choose from between NSAID's.
They all tend to be, more or less, the same, and if someone does not
respond to one they are unlikely to respond to another (no matter what
the drug companies say).

I think a review of the diagnosis might be worthwhile.  Joint
infections?  Are you sure?

Other medications which can be used or added are chloroquine, or low
doses of prednisone.  ASA could also be used.  I do not understand, to
tell you the truth, the approach of changing medications all the time,
rather than using one to its maximum and then adding something else,
if the first has little effect, because often medications which have
no effect alone, can work very well, say, with 5 or 10 mg of
prednisone daily in addition, with the possibility of weaning from the
prednisone after control is achieved.  This information is from my old
days, before I became a pediatrician, and perhaps the approach has
changed.

Jack Newman, MD, FRCPC

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