To      :  Theresa Chambliss
Re      :  Oxytocin Nasal spray

Syntocinon nasal spray provided by Sandoz in the past contained 40 IU/ml  of
oxytocin in a buffered saline solution with some preservatives.  As such, the
only other ingredients were glycerin and sorbitol, which were probably added as
preservatives or stabilizers rather than to enhance the absorption of oxytocin.

The dose used was rather obscure ( 1 spray in each nostril) prior to
breastfeeding.  If we were to ASSUME that 1 spray was about 3 drops, the dose
applied via two sprays would be about 12 IU of oxytocin or less.

Oxytocin as available in hospitals today contains 10 IU/cc in 1 and 10 cc vials
(Pitocin).  A pediatrician colleague of mine used this formulation at a dose of
8 drops in each nostril and found it produced a wonderful letdown in his
patient. Also,  one could purchase a bottle of Afrin(or any nasal spray), pop
the top, WASH IT OUT, and replace with the oxytocin injectible.  Then adjust
dose according to need. Keep refrigerated.

We know that patients who use oxytocin for long periods ( > 1 week) may become
quite tolerant (tachyphylaxis) to oxytocin and cannot have a normal letdown
without it.  So it is probably wise to suggest a weaning after 1 week.

The average wholesale price of IV oxytocin solution (10ml) varies from $4 to
$7.00 per 10 ml(generic and Pitocin).

Regards

Tom Hale, Ph.D.