According to Dr. Hale's 1997 edition (pg 570), tolbutamide (Orinase) is
approved by AAP for use in BF women. It's 93% protein bound, so little
gets into the milk. Observe infant for signs of jaundice and hypoglycemia.
Ref: Moiel RH, Ryan JR. Tolbutamide (Orinase) in human breast milk.
Clin Pediatr 6:480, 1967.
Becky Saenz, MD
Assistant Professor
University of MS Medical Center
Department of Family Medicine
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