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Date: | Tue, 14 Jan 1997 08:39:22 -0600 |
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Ann C.
Fludeoxyglucose is an analog of glucose that enters most all tissues of the
body according to their metabolic rate. The radioactive ion 18(F), has a
half-life of 110 minutes. It would undoubtedly enter breast milk.
I would recommend to pump and discard milk after the procedure to reduce
radioactive exposure of the breast tissue. The manufacturer recommends routine
bladder emptying for the same reason. According to the USPDI(1982) the mother
should wait 12-24 hours before breastfeeding her infant. In 9 hours, 97% of
the isotope will be decayed away. Were the mother to pump and dump for 12
hours, and then feed her infant, certainly most all of the radioactive
fluoride would be gone.
Tom Hale
FLUDEOXYGLUCOSE F 18 ((18)F) is E.Clin Appl
rapidly cleared from plasma after intravenous doses, and F.Reference
enters cells in a manner similar to glucose; it is G.Author
phosphorylated intracellularly by hexokinase to
fludeoxyglucose F 18-6-phosphate but, unlike
glucose-6-phosphate, is not metabolized further. Uptake
and accumulation of (18)F in tissues occurs in proportion
to the rate of glucose metabolism, and this can be
measured by PET; hypometabolism or hypermetabolism of CUUP Up 1
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glucose is characteristic of many diseases. Uptake of PREV Up 1
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(18)F is greatest in the bladder wall, heart, spleen, and NEXT Dn 1
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brain. Up to 20% of an intravenous dose of (18)F is F11 Last
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excreted in the urine within two hours. The physical F1 HELP
half-life of (18)F is 110 minutes.
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