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Date: | Fri, 20 Dec 1996 09:54:11 -0600 |
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To : Georgeanne
RE : Lidocaine
This is from an upcoming article i've just finished on anesthetics:
Lidocaine enters milk to a limited degree. In one study of a breastfeeding
mother who received IV lidocaine for ventricular arrhythmias, the mother
received approximately 965 mg over 7 hours including the bolus starting
doses(Zeisler 1986). At seven hours, breastmilk samples were drawn and the
concentration of lidocaine was 0.8 mg/L, or 40% of the maternal plasma level
(2.0 mg/L). Assuming that the mother's plasma was maintained at 5 µg/mL
(therapeutic = 1.5-5 µg/mL), an infant consuming 1 L per day of milk would
ingest approximately 2 mg/day. This amount is exceedingly low in view of the
fact that the oral bioavailability of lidocaine is very poor (35%). The
lidocaine dose recommended for pediatric arrhythmias is 1 mg/kg given as a
bolus. Once absorbed by the liver, lidocaine is rapidly metabolized. These
authors suggest that a mother could continue to breastfeed while on parenteral
lidocaine.
Lidocaine has a brief half-life of 1.8 hours...so most would be gone in 8-10
hours for sure.
Regards
Tom Hale, Ph.D.
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