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Subject:
From:
Tom Hale <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Thu, 13 Feb 1997 11:17:08 -0600
Content-Type:
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To      : Pat Lindsey
Re      : Parlodel (bromocriptine mesylate)

Bromocriptine is rapidly cleared from the body,  with a high first-pass
uptake(94%) by the liver.  Elimination half-life is about 6 hours.  So almost
total clearance would be attained in 30 hours.  Nevertheless,  bromocriptine
passes into milk only poorly.  One study has been reported of a mom receiving 5
mg/day for a pituitary tumor, with no untoward effects on the breastfed infant.

Oral bioavailability is poor, only 28% is orally absorbed.  I seriously doubt
there would be any problem in this breastfeeding mother.

Regards
Tom Hale

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