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Subject:
From:
Judy Knopf <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Sat, 4 Jan 1997 14:02:17 +0200
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TEXT/PLAIN
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Since I was asked to give a precis of the article on apoptosis, with a
feeling of abject humility, I'll give it my best shot (my academic
background is psychology, guys!)
This group of Swedish researchers cultured a human lung cancer cell line
and examined "effects of human milk and human milk fractions" on cell
viability. When the cancer cells were exposed to milk of 3 human donors,
it was seen that cancer cell viability fell to between 0-4%. Exposure to
bovine milk left 64-100% of the cancer cells alive. They took
the milk from the most "lethal" :)  human donor and fractionalized it,
discovering that the deadly element was in casein. They then
fractionalized the casein to discover that the very specific "multimeric
form of alpha-lactalbumin in human milk induces [lung cancer line A549] cell
death". Bovine milk alpha-lactalbumin fraction left alive 93-82% of the
cancer cells, and human alpha-lactalbumin left alive 92-80% of the cancer
cells. Apoptosis of the cancer cells was therefore extremely specific for
the multimeric alpha-lactalbumin fraction of human milk.
If there is anything faulty with this explanation, please forgive and
correct me. It was pretty difficult to wade through all the methods and
results. Looking forward to comments. Judy Knopf

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