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Date: | Tue, 18 Feb 1997 09:12:04 -0700 |
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It should also be noted that there is melatonin detectable in human milk,
but only during the night where its concentration was 280 +/- 34 pmol/L in
serum and 99 +/- 26 pmol/L in milk. The authors conjectured thatt he
presence of the rhythm in milk suggests that melatonin fluctuations in milk
might communicate time of day information to breast-fed infants. I would
agree that one should therefore start with small doses and carefully
observe the child, especially for sleep/wake disturbances. I would guess
that it would be best to avoid taking it early in the day, as well. Since
most poeple take it for the somnolent effect, that should not be a major
problem.
(Illnerova H; Buresova M; Presl J. Melatonin rhythm in human milk. Journal
of Clinical Endocrinology and Metabolism, 1993 Sep, 77(3):838-41.)
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