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Wed, 1 Jan 1997 12:55:23 -0600 |
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Texas Tech University |
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To : Ilene
Re : Ultram(tramidol)
Ultram is a new opioid-like analgesic. It is included in my '96
Edition, but I have enclosed a monograph below.
TRAMADOL
Tramadol is a new class analgesic that most closely resembles the
opiates, although it is not a controlled substance and appears to have
reduced addictive potential. It appears to be slightly more potent than
codeine. After oral use, its onset of analgesia is within 1 hour and
reaches a peak in 2-3 hours. Following a single IV 100 mg dose of
tramadol, the cumulative excretion in breastmilk within 16 hours was
100 ug of tramadol (0.1% of the maternal dose) and 27 ug of the M1
metabolite. The manufacturer does not recommend use in lactating women
because its safety in pediatric patients is unknown.
Half-life= 7 hrs
M/P ratio = 0.1
Oral Bioavail = 60%
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To : Denise
Re : Diflucan(fluconazole)
Diflucan is now available in a liquid formulation, you do not need to
crush tablets or formulate it. Current formulations contain 10 and 40
mg/ml of solution. Recommended dosing for infants is 6 mg/kg/day stat,
followed by 3 mg/kg/day thereafter. It is only cleared by the
manufacturer for infants 6 months and older, but as you stated, it is
commonly used in NICU's.
Regards
Tom Hale, Ph.D.
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