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Date: | Wed, 29 May 1996 09:11:27 -0500 |
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Someone asked about Zithromax, a macrolide erythromycin-like antibiotic.
Below is a recent reference.
Tom Hale
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Azithromycin Fax # 1032
Trade: Zithromax
Uses: Erythromycin-like antibiotic
AAP: Not reviewed
Azithromycin belongs to the erythromycin family. Extremely long half-life
particularly in tissues. Azithromycin is concentrated for long periods in
phagocytes which are known to be present in human milk. In one study of a
patient who received 1 gm initially, followed by two 500mg doses at 24 hr
intervals, the concentration of azithromycin in breastmilk varied from
0.64 mg/L (initially) to 2.8 mg/L on day 3. The predicted dose of
azithromycin received by the infant would be approximately 0.482 mg/day
(assuming milk volume of 150 mL/day and 37% bioavailability). This would
suggest that the level of azithromycin ingested by a breastfeeding infant
is not clinically significant. New pediatric formulations of azithromycin
have been recently introduced. Pediatric dosing is 10 mg/kg STAT,
followed by 5 mg/kg per day for up to 5 days.
Adverse Effects: Diarrhea, loose stools, abdominal pain, vomiting, nausea
AHL= 48-68 hours M/P=
PHL= PB = 7-51%
PK = 3-4 hours Oral= 37%
References:
1. Pharmaceutical Manufacturers Package Insert, 1996.
2. Kelsey JJ, Moser LR, Jennings JC, et.al. Presence of azithromycin
breast milk concentrations: A case report. Am. J. Obstet. Gynecol.
170:1375-6,
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