The half-life of methotrexate is 8-15 hours.
Using the best case scenario of 8 hours, 5 half-lives (over 95% elimination of drug from plasma and milk),
would be 40 hours.
If the mother's renal function is fine, considering the child is 9 months old,
and the RID for methotrexate is 0.1%, I would go with the best case scenario of 40 hours.
Frank J. Nice, RPh, DPA, CPHP
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