Dear Lactnet Friends:
So there is really a safe dose of perchlorate???? ('scuse me while I go
vomit....we are talking about our precious babies here!!!)
J Expo Sci Environ Epidemiol. 2010 May;20(3):281-7. Epub 2009 Mar 18.
Perchlorate exposure from infant formula and comparisons with the
perchlorate reference dose.
Schier JG<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Schier%20JG%22%5BAuthor%5D>
, Wolkin AF<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Wolkin%20AF%22%5BAuthor%5D>
, Valentin-Blasini
L<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Valentin-Blasini%20L%22%5BAuthor%5D>
, Belson MG<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Belson%20MG%22%5BAuthor%5D>
, Kieszak SM<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Kieszak%20SM%22%5BAuthor%5D>
, Rubin CS<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Rubin%20CS%22%5BAuthor%5D>
, Blount BC<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Blount%20BC%22%5BAuthor%5D>
.
Division of Environmental Hazards and Health Effects, National Center for
Environmental Health, Centers for Disease Control and Prevention, Atlanta,
Georgia 30341, USA. [log in to unmask]
Abstract
Perchlorate exposure may be higher in infants compared with older persons,
due to diet (infant formula) and body weight versus intake considerations.
Our primary objective was to quantitatively assess perchlorate
concentrations in commercially available powdered infant formulas (PIFs).
Secondary objectives were: (1) to estimate exposure in infants under
different dosing scenarios and compare them with the perchlorate reference
dose (RfD); (2) estimate the perchlorate concentration in water used for
preparing PIFs that would result in a dose exceeding the RfD; and (3)
estimate iodine intakes from PIFs.
We quantified perchlorate levels in three samples (different lot numbers) of
reconstituted PIF (using perchlorate-free water) from commercial brands of
PIF in each of the following categories: bovine milk-based with lactose,
soy-based, bovine milk-based but lactose-free, and elemental (typically
consisting of synthetic amino acids). Exposure modeling was conducted to
determine whether the RfD might be exceeded in 48 dosing scenarios that were
dependent on age, centile energy intake per unit of body weight, body weight
percentile, and PIF perchlorate concentration. We obtained three different
samples in each of the five brands of bovine- and soy-based PIF, three
different samples in each of the three brands of lactose-free PIF, and three
different samples in two brands of elemental PIF.
The results were as follows: bovine milk-based with lactose (1.72 microg/l,
range: 0.68-5.05); soy-based (0.21 microg/l, range: 0.10-0.44); lactose-free
(0.27 microg/l, range: 0.03-0.93); and elemental (0.18 microg/l, range:
0.08-0.4). Bovine milk-based PIFs with lactose had a significantly higher
concentration of perchlorate (P<0.05) compared with all.
Perchlorate was a contaminant of all commercially available PIFs tested.
Bovine milk-based PIFs with lactose had a significantly higher perchlorate
concentration perchlorate than soy, lactose-free, and elemental PIFs. The
perchlorate RfD may be exceeded when certain bovine milk-based PIFs are
ingested and/or when PIFs are reconstituted with perchlorate-contaminated
water.
warmly,
Nikki Lee RN, BSN, Mother of 2, MS, IBCLC, CCE, CIMI, ANLC
craniosacral therapy practitioner
www.breastfeedingalwaysbest.com
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