Dear Lactnet Friends:
Pediatrics. <http://www.ncbi.nlm.nih.gov/pubmed/21262884> 2011 Jan 24. [Epub
ahead of print]
Effects of Recombinant Human Prolactin on Breast Milk Composition.
Powe CE<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Powe%20CE%22%5BAuthor%5D>
, Puopolo KM<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Puopolo%20KM%22%5BAuthor%5D>
, Newburg DS<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Newburg%20DS%22%5BAuthor%5D>
, Lönnerdal B<http://www.ncbi.nlm.nih.gov/pubmed?term=%22L%C3%B6nnerdal%20B%22%5BAuthor%5D>
, Chen C<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Chen%20C%22%5BAuthor%5D>
, Allen M<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Allen%20M%22%5BAuthor%5D>
, Merewood A<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Merewood%20A%22%5BAuthor%5D>
, Worden S<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Worden%20S%22%5BAuthor%5D>
, Welt CK<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Welt%20CK%22%5BAuthor%5D>
.
Harvard Medical School, Harvard University, Boston, Massachusetts;
Abstract
Objective: The objective of this study was to determine the impact of
recombinant human prolactin (r-hPRL) on the nutritional and immunologic
composition of breast milk. Methods: We conducted 2 trials of r-hPRL
treatment. In the first study, mothers with documented prolactin deficiency
were given r-hPRL every 12 hours in a 28-day, open-label trial. In the
second study, mothers with lactation insufficiency that developed while they
were pumping breast milk for their preterm infants were given r-hPRL daily
in a 7-day, double-blind, placebo-controlled trial. Breast milk
characteristics were compared before and during 7 days of treatment.
Results: Among subjects treated with r-hPRL (N = 11), milk volumes (73 ± 36
to 146 ± 54 mL/day; P < .001) and milk lactose levels (155 ± 15 to 184 ± 8
mmol/L; P = .01) increased, whereas milk sodium levels decreased (12.1 ± 2.0
to 8.3 ± 0.5 mmol/L; P = .02). Milk calcium levels increased in subjects
treated with r-hPRL twice daily (2.8 ± 0.6 to 5.0 ± 0.9 mmol/L; P = .03).
Total neutral (1.5 ± 0.3 to 2.5 ± 0.4 g/L; P = .04) and acidic (33 ± 4 to 60
± 6 mg/L; P = .02) oligosaccharide levels increased in r-hPRL-treated
subjects, whereas total daily milk immunoglobulin A secretionwas unchanged.
Conclusions: r-hPRL treatment increased milk volume and induced changes in
milk composition similar to those that occur during normal lactogenesis.
r-hPRL also increased antimicrobially active oligosaccharide concentrations.
These effects were achieved for women with both prolactin deficiency and
lactation insufficiency.
--
Nikki Lee RN, BSN, Mother of 2, MS, IBCLC, CCE, CIMI, ANLC
craniosacral therapy practitioner
www.breastfeedingalwaysbest.com
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