This was in PEDIATRICS, Volume 125, Number 1, January 2010

 

E107 ABSTRACT           

 

Effect of Domperidone on the composition of preterm Human Breast Milk

 

Looks like the study was out of Canada.

 

"Objective:  Domperidone is increasingly prescribed to improve breast milk
volume despite a lack of evidence regarding its effects on breast milk
composition.  We examined the effect of Domperidone on the nutrient
composition of breast milk.

 

Patients and Methods:  Forty-six mothers who had delivered infants at <31
weeks' gestation, who experienced lactation failure, were randomly assigned
to receive Domperidone or placebo for 14 days.  Protein, energy, fat,
carbohydrate, sodium, calcium, and phosphate levels in breast milk were
measured on days 0,4,7,14,serum prolactin levels were measured on days
0,4,7,14, and total milk volume we recorded daily.  Mean within-subject
changes in nutrients and milk volumes were examined.

 

Results:  Maternal and infant characteristics, serum prolactin level, and
breast milk volume and composition were not significantly different between
Domperidone and placebo groups on day 0.  By day 14, breast milk volumes
increased by 267% in the Domperidone-treated group and by 18.5% in the
placebo group.  Serum prolactin increased by 97% in the Domperidone group
and by 17%in the placebo group.  Mean breast milk protein declined by 9.6%
in the Domperidone group and increased by 3.6% in the placebo group.
Changes in energy, fat, carbohydrate, sodium, and phosphate content were
also not significantly different between groups.  Significant increases were
observed in breast milk carbohydrate and calcium in the Domperidone versus
placebo ratio.  N significant adverse events were observed among mothers or
infants.

 

Conclusion:  Domperidone increases the volume of breast milk of preterm
mothers experiencing lactation failure, without substantially altering the
nutrient composition."

 

 

NOW IS WE CAN JUST GET THE UNITED STATES ON BOARD!!!!!!!!!!!!!!!!!!!!  

 

Linda Hill RN, IBCLC

Austin, TX

Capital Pediatric Group

 


             ***********************************************

Archives: http://community.lsoft.com/archives/LACTNET.html
To reach list owners: [log in to unmask]
Mail all list management commands to: [log in to unmask]
COMMANDS:
1. To temporarily stop your subscription write in the body of an email: set lactnet nomail
2. To start it again: set lactnet mail
3. To unsubscribe: unsubscribe lactnet
4. To get a comprehensive list of rules and directions: get lactnet welcome