* *Pediatr Allergy Immunol. <javascript:AL_get(this, 'jour', 'Pediatr
Allergy Immunol.');> 2009 Oct 14. [Epub ahead of print]
Effect of probiotic mix (Bifidobacterium bifidum, Bifidobacterium lactis,
Lactobacillus acidophilus) in the primary prevention of eczema: a
double-blind, randomized, placebo-controlled trial.*Kim
JY*<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Kim%20JY%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>
, *Kwon JH*<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Kwon%20JH%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>
, *Ahn SH*<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Ahn%20SH%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>
, *Lee SI*<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Lee%20SI%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>
, *Han YS*<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Han%20YS%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>
, *Choi YO*<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Choi%20YO%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>
, *Lee SY*<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Lee%20SY%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>
, *Ahn KM*<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Ahn%20KM%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>
, *Ji GE*<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Ji%20GE%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>
.

Department of Food and Nutrition, College of Human Ecology, Seoul National
University, San 56-1, Shinlimdong, Kwanakku, Seoul, Korea.

Controversy exists regarding the preventive effect of probiotics on the
development of eczema or atopic dermatitis. We investigated whether
supplementation of probiotics prevents the development of eczema in infants
at high risk. In a randomized, double-blind, placebo-controlled trial, 112
pregnant women with a family history of allergic diseases received a
once-daily supplement, either a mixture of Bifidobacterium bifidum BGN4, B.
lactis AD011, and Lactobacillus acidophilus AD031, or placebo, starting at
4-8 wks before delivery and continuing until 6 months after delivery.
Infants were exclusively breast-fed during the first 3 months, and were
subsequently fed with breastmilk or cow's milk formula from 4 to 6 months of
age. Clinical symptoms of the infants were monitored until 1 yr of age, when
the total and specific IgE against common food allergens were measured. A
total of 68 infants completed the study. The prevalence of eczema at 1 yr in
the probiotic group was significantly lower than in the placebo group (18.2%
vs. 40.0%, p = 0.048). The cumulative incidence of eczema during the first
12 months was reduced significantly in probiotic group (36.4% vs. 62.9%, p =
0.029); however, there was no difference in serum total IgE level or the
sensitization against food allergens between the two groups. Prenatal and
postnatal supplementation with a mixture of B. bifidum BGN4, B. lactis
AD011, and L. acidophilus AD031 is an effective approach in preventing the
development of eczema in infants at high risk of allergy during the first
year of life.

-- 
Nikki Lee RN, BSN, Mother of 2, MS, IBCLC, CCE, CIMI
craniosacral therapy practitioner
www.breastfeedingalwaysbest.com

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