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Mon, 29 Mar 2010 19:45:36 +0000 |
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A 40-year -old woman was taking cefpodoxime (Vantin and others) 200 mg twice daily for 4 days for fever and cough. She complained of milk from both breasts that started 2 days of this antibiotic treatment. She had no central nervous system complaints and reported no sexual activity for 10 days. A serum pregnancy test was performed, which was negative. She had not recently had a child nor was she breastfeeding. She had normal renal function and her thyroid-stimulating hormone level was normal. The serum prolactin level was measured at 6,854 pmol/L (for menopausal women, normal is 625 to 4,028 pmol/L). A magnetic resonance imaging of her brain was normal.
The cefpodoxime was discontinued and by 1 week later the prolactin level had fallen to 1,111 pmol/L and the breast discharge stopped. One month later, the prolactin level was down to 778 pmol/L.
The authors report that this is the first report of galactorrhea associated with cefpodoxime-induced hyperprolactinemia. Other drugs known to cause galactorrhea through antidopaminergic effects include antipsychotic agents and metoclopramide.
Khurana V, Gambhir IS. Cefpodoxime-induced hyperprolactinemic galactorrhea. Ann Intern Med. 2010; 152 (2):136.
Frank J. Nice, RPh, DPA, CPHP
Check out my Website and Book, "Nonprescription Drugs for the Breastfeeding Mother" at:
www.nicebreastfeeding.com
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