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Date: | Thu, 30 Apr 2009 21:58:07 +0000 |
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Infliximab (Remicade) is a monoclonal antibody to TNF-alpha used to treat Crohn's disease and rheumatoid arthritis. Infliximab is a very large molecular weight antibody and is largely retained in the vascular system. In a study of one breastfeeding patient who received 5 mg/kg IV, infliximab levels were determined in milk at 0, 2, 4, 8, 24, 48, 72 hours, and 4, 5, and 7 days. None was detected in milk at any time (detection limit <0.1 micrograms/mL).
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Infliximab is pobably too large to enter milk in clinically measurable amounts. It would not be orally available.
Cited from Medications and Mothers' Milk, Thomas W. Hale, PhD, 2008 edition.
~spencer
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E. Spencer Joslin-Montlick, MD
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