LACTNET Archives

Lactation Information and Discussion

LACTNET@COMMUNITY.LSOFT.COM
Options: Use Forum View

Use Monospaced Font
Show Text Part by Default
Show All Mail Headers

Message: [<< First] [< Prev] [Next >] [Last >>]
Topic: [<< First] [< Prev] [Next >] [Last >>]
Author: [<< First] [< Prev] [Next >] [Last >>]

Print Reply
Subject:
Remicade is L2
From:
"E. Spencer Joslin-Montlick, MD" <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Thu, 30 Apr 2009 21:58:07 +0000
Content-Type:
text/plain
Parts/Attachments:
text/plain (42 lines) 
Infliximab (Remicade) is a monoclonal antibody to TNF-alpha used to treat Crohn's disease and rheumatoid arthritis.  Infliximab is a very large molecular weight antibody and is largely retained in the vascular system.  In a study of one breastfeeding patient who received 5 mg/kg IV, infliximab levels were determined in milk at 0, 2, 4, 8, 24, 48, 72 hours, and 4, 5, and 7 days.  None was detected in milk at any time (detection limit <0.1 micrograms/mL). 



... 



Infliximab is pobably too large to enter milk in clinically measurable amounts.  It would not be orally available. 



Cited from Medications and Mothers' Milk, Thomas W. Hale, PhD, 2008 edition. 



~spencer 




%%%%%%%%%%%%%%%%%%%% 

       E. Spencer Joslin-Montlick, MD 

            [log in to unmask]   



%%%%%%%%%%%%%%%%%%%% 

             ***********************************************

Archives: http://community.lsoft.com/archives/LACTNET.html
To reach list owners: [log in to unmask]
Mail all list management commands to: [log in to unmask]
COMMANDS:
1. To temporarily stop your subscription write in the body of an email: set lactnet nomail
2. To start it again: set lactnet mail
3. To unsubscribe: unsubscribe lactnet
4. To get a comprehensive list of rules and directions: get lactnet welcome

ATOM RSS1 RSS2