Hi- I'm trying to remember if this was addressed by Dr. Hale at the LLL physician conference this summer, and I believe the response was that there was no point in using it prenatally as it won't work. Before birth, prolactin's effect on milk secretion is inhibited by high levels of progesterone (progesterone is a prolactin inhibitor). After expulsion of the placenta, progesterone levels fall and Lactogenesis II begins (source: Core Curriculum for Lactation Consultant Practice). As Domperidone increases prolactin levels (if I understand it's mechanism correctly), I can see no point in taking it prenatally. I would also want to check what pregnancy risk category to determine if it would do harm to a pregnant woman. These are just my thoughts/opinion. 
Stacy D. Kucharczk, MSN, RN, CPNP, IBCLC

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