Hi! 
   
  About Risperidone, I´ve read on a reliable web page (www.e-lactanica.org, web page of the Pediatric Service of Marina Alta Hospital, a BFHI hospital here in Spain) that the level of risk is low.
   
  It makes sense because of the pharmacokinetics:
  Molecular weight: 411 (the greater the mw, the less the medication passes into the milk; at 500 almost nothing passes).
   
  Protein binding: 90 % (the more it binds to protein, the less it passes into the milk; more than 80% is high binding).
   
  Milk/plasma ratio: 0,4 (the lower it is <1, the less concentration the medication reaches in the milk).
   
  Theoretical dose the baby would receive: 0.007 mg/kg/day which is very very low.
   
  The half life of risperidone is 3 hours, so as an extra protective measure the mother could breastfeed the baby, take the medication and then wait for three hours before nursing again.
   
  Hope that helps!
   
  Kika
   


Kika Baeza, MD, IBCLC, family doc
www.centroraices.com
Madrid, Spain
 		
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