RE Denise Parker's case:
>>  Mother has a history of very low levels of estrogen.  They used "mega
doses" (her term)  of clomid to enable her to conceive.<<
Lawrence (1994 ed)  in her section on physiology has many references to
estrogen's involvement in breast development.  I found this one that seems to
indicate that lack of  estrogen is not the problem: " Estogens enhance the
effect of prolactin on mammogenesis but antagonize prolactin by inhibiting
the secretion of milk." (pg 66)
>>Her breasts were very assymetrical as a teen and she had reduction in one
to even them out.  They are still assymetrical but neither is producing.  I
immediately thought of insufficient mammary tissue
however they look normal with no tubular shape to them at all.<<
From your comments, it sounds more like lack of tissue.  I have found that
shape is irrevelent with insufficent glandular development. How about an
ultra sound of the breasts?

Re: Linda's Smith's case
When a woman is morbidly obese (you din't say how overweight this mom is) my
understanding is that they have problems with high estrogen levels. A friend
is more than 100# overweight and has very irregular periods. The GYN says
excessive body weight is related to overproduction of estrogen causing a
rebound effect making the periods irregular. She was told it is not unlike
the effect of BCP's. She has also been warned that she would be more likely
to get breast cancer. I know of many women who were seemly infertile until
they lost weight.
Given this mom's weight and overproduction any chance she has a pitutary
tumor or other hormonal imbalance?