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Lactation Information and Discussion <[log in to unmask]>
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"Nice, Frank (NIH/NINDS)" <[log in to unmask]>
Date:
Mon, 14 Apr 2003 10:33:29 -0400
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Lactation Information and Discussion <[log in to unmask]>
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Infant levels as high as 9% of maternal levels.  Metabolite present in low
but detectable concentrations in infants.  No adverse effects notes, but
monitor for agitation, insomnia, and poor feeding.  Use alternative SSRI if
possible.

Ilett KF, Hackett LP, Dusci LJ, et al. Distribution and excretion of
venlafaxine and o-desmethylvenlafaxine in human milk.  Br J Clin Pharmacol
1998; 45: 459-62.

Ilett KF, Kristensen JH, Hackett LP, et al. Distribution of venlafaxine
o-desmethylvenlafaxine in human milk. Br J Clin Pharmacol 2002; 53: 17-22.

Frank J. Nice, DPA, CPHP

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