Sorry, the link is there also at Mercola's website.  This is out of
Canada and it for premies, by the way.
Judy Ritchie


Pediatrics 2002 Sep;110(3):523-8
Related Articles, Links 
  
Routine sucrose analgesia during the first week of life in neonates
younger than 31 weeks' postconceptional age.

Johnston CC, Filion F, Snider L, Majnemer A, Limperopoulos C, Walker CD,
Veilleux A, Pelausa E, Cake H, Stone S, Sherrard A, Boyer K.

McGill University, School of Nursing, Montreal, QC, Canada.
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OBJECTIVE: To determine the efficacy of sucrose analgesia for procedural
pain during the first week of life in preterm neonates in neonatal
intensive care units on enhancing later clinical outcomes. METHODS: A
total of 107 preterm neonates who were born at <31 weeks'
postconceptional age (PCA) entered this double-blind, randomized,
controlled trial within 48 hours of birth at 3 level III
university-affiliated neonatal intensive care units in Canada, and 103
completed the study. Sucrose (0.1 mL of 24%) or sterile water was
administered orally up to 3 times, 2 minutes apart, for every invasive
procedure during a 7-day period. Motor development and vigor, and
alertness and orientation components of the Neurobehavioral Assessment
of the Preterm Infant were measured at 32, 36, and 40 weeks' PCA; Score
for Neonatal Acute Physiology was measured on the last day of
intervention; and Neuro-Biological Risk Score (NBRS) was measured at 2
weeks of age and at discharge. Primary analyses of covariance were
applied for each outcome to compare group differences followed by
secondary analyses using standard linear regression within each group to
determine predictors of outcomes. RESULTS: Although there were no
differences between the groups on any outcomes, there were significant
dose-related effects within each group. In the sucrose group only,
higher number of doses of sucrose predicted lower scores on motor
development and vigor, and alertness and orientation at 36 weeks', lower
motor development and vigor at 40 weeks', and higher NBRS at 2 weeks'
postnatal age. Higher number of invasive procedures was predictive of
higher NBRS both times in the water group. CONCLUSIONS: Repeated use of
sucrose analgesia in infants <31 weeks' PCA may put infants at risk for
poorer neurobehavioral development and physiologic outcomes. Additional
study is needed to determine the most appropriate age and duration of
sucrose analgesia in preterm infants.

PMID: 12205254 [PubMed - in process] 

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